The
hemorrhage occurred at every meal and lasted ten minutes. There
is no evidence that the woman was of hemophilic descent.
Of 334 cases of bleeding in hemophilia collected by Grandidier,
169 were from the nose, 43 from the mouth, 15 from the stomach,
36 from the bowels, 16 from the urethra, 17 from the lungs, and a
few from the skin of the head, eyelids, scrotum, navel, tongue,
finger-tips, vulva, and external ear. Osler remarks that
Professor Agnew knew of a case of a bleeder who had always bled
from cuts and bruises above the neck, never from those below. The
joint-affections closely resemble acute rheumatism. Bleeders do
not necessarily die of their early bleedings, some living to old
age. Oliver Appleton, the first reported American bleeder, died
at an advanced age, owing to hemorrhage from a bed-sore and from
the urethra. Fortunately the functions of menstruation and
parturition are not seriously interfered with in hemophilia.
Menstruation is never so excessive as to be fatal. Grandidier
states that of 152 boy subjects 81 died before the termination of
the seventh year. Hemophilia is rarely fatal in the first year.
Of the hemorrhagic diseases of the new-born three are worthy of
note.
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