Lewin says that in this case the severity of the eruption was in
accordance with the size of the dose, and during its existence
there was bleeding at the gums; he adds that Gouchet also noticed
an eruption of this kind in a lady who after taking quinin
expectorated blood. The petechiae were profusely spread over the
entire body, and they disappeared after the suspension of the
drug. Dauboeuf, Garraway, Hemming, Skinner, and Cobner mention
roseola and scarlatiniform erythema after minute doses of quinin.
In nearly all these cases the accompanying symptoms were
different. Heusinger speaks of a lady who, after taking 1/2 grain
of quinin, experienced headache, nausea, intense burning, and
edema, together with nodular erythema on the eyelids, cheeks, and
portion of the forehead. At another time 1 1/2 grains of the drug
gave rise to herpetic vesicles on the cheeks, followed by branny
desquamation on elimination of the drug. In other patients
intense itching is experienced after the ingestion of quinin.
Peters cites an instance of a woman of sixty-five who, after
taking one grain of quinin, invariably exhibited after an hour a
temperature of from 104 degrees to 105 degrees F., accelerated
pulse, rigors, slight delirium, thirst, and all the appearances
of ill-defined fever, which would pass off in from twelve to
twenty-four hours.
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