She suffered
greatly from itching of the skin, due to the uremia of the
kidney-disease; the skin was harsh and dry. For this symptom
fluid extract of jaborandi was prescribed with the effect of
relieving the itching. It was taken in doses of 20 or 30 drops
several times a day, from October, 1886, to February, 1888.
During the fall of 1887 it was noticed by the nurse that the
eyebrows were growing darker, and that the hair of the head was
darker in patches. These patches and the eyebrows continued to
become darker, until at the time of her death they were quite
black, the black tufts on the head presenting a very curious
appearance among the silver-white hairs surrounding them.
Quinin being such a universally used drug, numerous instances of
idiosyncrasy and intolerance have been recorded. Chevalier
mentions that through contact of the drug workmen in the
manufacture of quinin are liable to an affection of the skin
which manifests itself in a vesicular, papular, or pustular
eruption on different parts of the body. Vepan mentions a lady
who took 1 1/2 grains and afterward 2 1/2 grains of quinin for
neuralgia, and two days afterward her body was covered with
purpuric spots, which disappeared in the course of nine days but
reappeared after the administration of the drug was resumed.
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