Prentiss of Washington, D.C., in 1881 reported a remarkable case
of pilocarpin idiosyncrasy in a blonde of twenty-five. He was
consulted by the patient for constipation. Later on symptoms of
cystitis developed, and an ultimate diagnosis of pyelitis of the
right kidney was made. Uremic symptoms were avoided by the
constant use of pilocarpin. Between December 16, 1880, and
February 22, 1881, the patient had 22 sweats from pilocarpin. The
action usually lasted from two to six hours, and quite a large
dose was at length necessary. The idiosyncrasy noted was found in
the hair, which at first was quite light, afterward
chestnut-brown, and May 1, 1881, almost pure black. The growth of
the hair became more vigorous and thicker than formerly, and as
its color darkened it became coarser in proportion. In March,
1889, Prentiss saw his patient, and at that time her hair was
dark brown, having returned to that color from black. Prentiss
also reported the following case a as adding another to the
evidence that jaborandi will produce the effect mentioned under
favorable circumstances: Mrs. L., aged seventy-two years, was
suffering from Bright's disease (contracted kidney). Her hair and
eyebrows had been snow-white for twenty years.
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