It consisted of closely disposed papules of the
size of a pin-head, and several days after the disappearance of
the eruption a fine, bran-like desquamation of the epidermis
ensued. Brand has also seen an eruption on the trunk and flexor
surfaces, accompanied with fever, from the ingestion of opium.
Billroth mentions the case of a lady in whom appeared a feeling
of anxiety, nausea, and vomiting after ingestion of a small
fraction of a grain of opium; she would rather endure her intense
pain than suffer the untoward action of the drug. According to
Lewin, Brochin reported a case in which the idiosyncrasy to
morphin was so great that 1/25 of a grain of the drug
administered hypodermically caused irregularity of the
respiration, suspension of the heart-beat, and profound narcosis.
According to the same authority, Wernich has called attention to
paresthesia of the sense of taste after the employment of
morphin, which, according to his observation, is particularly
prone to supervene in patients who are much reduced and in
persons otherwise healthy who have suffered from prolonged
inanition. These effects are probably due to a central excitation
of a similar nature to that produced by santonin.
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